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■ A Novofumigatamide, New Cyclic Tripeptide from Aspergillus novofumigatus

Kazuki Ishikawa, Tomoo Hosoe,* Takeshi Itabashi, Kayoko Takizawa, Takashi Yaguchi, and Ken-ichi Kawai

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A new cyclic tripeptide, novofumigatamide (1) has been isolated from Aspergillus novofumigatus CBS117520. The relative structure of 1 was established on the basis of spectroscopic and physico-chemical data and chemical investigations. The absolute structure of 1 was determined by using a Marfey’s method. Compound 1 showed non-specific antifungal activities against some human pathogenic fungi and did not inhibit cell proliferation for any tumor cells.