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Paper | Regular issue | Vol 81, No. 10, 2010, pp.2247-2256
Published online, 11th August, 2010
DOI: 10.3987/COM-10-11999
Synthesis and Antimicrobial Evaluation of Some New Pyridine Based Heterocycles

Elham S. Darwish, Nabila A. Kheder, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt


A facile and convenient synthesis of pyridine, pyridazine, 2(3H)-1,3,4-thiadiazole and pyrazole derivatives incorporating a pyridine-2-ylcarboxamido moiety via the versatile, readily accessible 3-oxo-N-(pyridin-2-yl)butanamide is described. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed moderate activity.