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Paper | Regular issue | Vol 81, No. 8, 2010, pp.1843-1859
Published online, 10th June, 2010
DOI: 10.3987/COM-10-11976
■ Novel Synthesis of 2-Alkoxy(Aralkoxy)-5-chloro[1,2,4]triazolo[1,5-a]quinazolines and Their Derivatives

Rashad Al-Salahi* and Detlef Geffken

*Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia

Abstract

2-Alkoxy(aralkoxy)-5-chloro[1,2,4]triazolo[1,5-a]quinazolines have been synthesized. The corresponding 2-alkoxy(aralkoxy)[1,2,4]triazolo[1,5-a]quinazolin-5-ones were chlorinated with either oxalyl chloride or phosphorus oxychloride. The chlorine atom at 5-position of the targeted [1,2,4]triazolo[1,5-a]quinazolines was replaced with multifunctional N-nucleophiles. This provided the preparation of the heterocyclic system bearing a variety of substituents at 5-position.