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Review | Regular issue | Vol 81, No. 8, 2010, pp.1773-1789
Published online, 10th June, 2010
DOI: 10.3987/REV-10-673
The Chemical and Biological Properties of Protopine and Allocryptopine

Jan Vacek,* Daniela Walterová, Eva Vrublová, and Vilím Šimánek

*Faculty of Medicine and Dentistry, Department of Medical Chemistry and Biochemistry, Palacký University, Hnevotínská 3, 77515 Olomouc, Czech Republic


The isoquinoline alkaloids, protopine and allocryptopine are components of numerous phytopreparations. The wide spectrum of biological activities reported for these alkaloids include multiple actions on the cardiovascular system, anti-thrombotic, anti-inflammatory, anti-spasmodic, neuroprotective, anti-bacterial, anti-viral, anti-fungal and anti-parasitic activities. This review aims to summarize recent knowledge on the basic chemistry, analysis, above biological activities, and application of both alkaloids published within the period 1995-2010.