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Note | Regular issue | Vol 81, No. 7, 2010, pp.1697-1702
Published online, 14th May, 2010
DOI: 10.3987/COM-10-11962
Improved Total Synthesis of Racemic Rutamarin

Ling Tong, Ruisheng Xiong, Hong Jiang, Xiangrui Jiang,* Hongbin Sun,* Hualiang Jiang, and Jingshan Shen

*Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zuchongzhi Rd., Zhangjiang Hi-Tech Park, Shanghai, 201203, China


An improved, convenient and cost-effective process, using 2,4-dihydroxybenzaldehyde 2 as starting material for (±)-rutamarin 1, is described. The overall yield of 1 is 44% in eight steps, requiring no chromatographic purification.