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Communication | Regular issue | Vol 81, No. 6, 2010, pp.1419-1426
Published online, 26th April, 2010
DOI: 10.3987/COM-10-11961
Synthesis and Anti-Hepatitis C Virus Activity of Morpholino Triazine Derivatives

Takashi Misawa, Mohammed T. A. Salim, Mika Okamoto, Masanori Baba,* Hiroshi Aoyama, Yuichi Hashimoto, and Kazuyuki Sugita*

*Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Abstract

A series of morpholino triazines was synthesized and evaluated for anti-hepatitis C virus (HCV) activity. Incorporation of OMe, CN and F into the phenyl moiety afforded analogues with moderate potency and good selectivity, as assessed with the subgenomic HCV RNA replicon assay.