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Note | Regular issue | Vol 81, No. 6, 2010, pp.1493-1502
Published online, 9th April, 2010
DOI: 10.3987/COM-10-11942
Pyrrolizidine Alkaloids from the Roots of Paris verticillata

Ki Hyun Kim, Kyu Ha Lee, Sang Un Choi, Kyung Ran Kim, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Korea

Abstract

Three new pyrrolizidine alkaloids, verticillatins A (1), B (2), and C (3), together with seven known pyrrolizidine alkaloids (4-10), were isolated from the roots of Paris verticillata (Liliaceae). Their structures were determined by spectroscopic data and chemical evidences. Verticillatin A (1), verticillatin B (2), verticillatin C (3), heliovinine N-oxide (4), and indicine N-oxide (5) showed cytotoxicity against the HCT15 cell line, with IC50 values of 67.6, 92.4, 35.7, 36.2, and 74.7 μM, respectively.