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Note | Regular issue | Vol 81, No. 6, 2010, pp.1485-1491
Published online, 23rd April, 2010
DOI: 10.3987/COM-10-11937
A Synthesis of β-Allyl Substituted Isotetronic Acid Derivatives via Thermal Claisen Rearrangement

Xiaping Ma, Zhiming Li, and Quanrui Wang*

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China


Isotetronic acids are of great interest in agricultural and pharmacological research and occur in a number of natural products. This paper describes the first Claisen rearrangement of the O-allyl substituted isotetronic acids 2 under thermal conditions furnishing the β-allyl substituted isotetronic acid derivatives 3 in high yields.