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Review | Special issue | Vol 82, No. 2, 2010, pp.1083-1101
Published online, 3rd September, 2010
DOI: 10.3987/REV-10-SR(E)7
Further Application of the Multi-Template Approach for Creation of Biological Response Modifiers: Discovery of a New Class of Multifunctional Anti-Diabetic Agents

Kazunori Motoshima, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, and Kazuyuki Sugita*

*Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan


We have previously employed the multi-template approach to create many types of biologically active compounds. In this review, we focus on extension of the multi-template approach to develop candidate anti-diabetic and anti-metabolic syndrome agents with a well-balanced range of activities.