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Paper | Regular issue | Vol 81, No. 6, 2010, pp.1435-1444
Published online, 9th April, 2010
DOI: 10.3987/COM-10-11931
Determination of the Structure and Its Absolute Configuration of 2”-Hydroxynicotianamine, an Inhibitor against Angiotensin-I Converting Enzyme in Buckwheat, through the Total Synthesis

Keisuke Yoshikawa,* Hidenori Watanabe, Yasuo Aoyagi, and Takeshi Kitahara

*Technical Research Institute, T. Hasegawa Co., Ltd., Kariyado, Nakahara-ku, Kawasaki city, Japan


Nicotianamine is known as an inhibitor against Angiotensin-I Converting Enzyme (ACE). We synthesized a new nicotianamine derivative with an additional hydroxy group isolated from buckwheat (Fagopyrum esculentum Moench) powder and determined its regio and stereochemistry unambiguously by the enantioselective synthesis of diastereomers.