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Review | Regular issue | Vol 81, No. 6, 2010, pp.1347-1392
Published online, 14th April, 2010
DOI: 10.3987/REV-10-667
Bridged Nucleic Acids: Development, Synthesis and Properties

Satoshi Obika,* S. M. Abdur Rahman, Aki Fujisaka, Yuji Kawada, Takeshi Baba, and Takeshi Imanishi*

*Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 560-0871, Japan

Abstract

Restricting the sugar moiety of a nucleic acid to a single conformation can be accomplished by forming a bridge in the sugar. A large number of bridged nucleic acids with variable bridged structures and conformations have been developed. The synthesis and properties of these artificial nucleic acid analogues are discussed. Such conformational restriction of the sugar moiety significantly improved the properties of the nucleic acid.