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■ Sunabedine, a Novel Toxic Bromotyrosine-derivative Alkaloid from Okinawan Sponge, Order Verongida

Norihito Maru, Tomoyuki Koyama, Osamu Ohno, Kaoru Yamada, and Daisuke Uemura*

*Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku Yokohama 223-8522, Japan

Abstract

Sunabedine (1), a new bromotyrosine-derivative alkaloid, was isolated from the Okinawan sponge, order Verongida. The structure of 1 was determined by spectroscopic analyses. 1 showed the cytotoxicity against B16 mouse melanoma cells and toxicity against brine shrimp.