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Paper | Regular issue | Vol 81, No. 3, 2010, pp.649-658
Published online, 28th January, 2010
DOI: 10.3987/COM-09-11887
Synthesis and Biological Activity of Mono- and Disubstituted 1,2,4-Triazole Derivatives

Vytautas Mickevičius,* Vida Intaitė, Aušra Voskienė, Kristina Kantminienė, Maryna Stasevych, Olena Komarovska-Porokhnyavets, and Volodymyr Novikov

*Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, Kaunas LT-50254, Lithuania


Novel mono- and disubstituted triazole derivatives were synthesized by condensation reactions of 1-aryl-3-hydrazinocarbonyl-5-oxopyrrolidinones with organic and inorganic cyanates, their structures were investigated and antimicrobial activity was evaluated.