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Paper | Regular issue | Vol 81, No. 4, 2010, pp.897-907
Published online, 9th February, 2010
DOI: 10.3987/COM-09-11885
Gymnastatins I-K, Cancer Cell Growth Inhibitors from a Sponge-Derived Gymnascella dankaliensis

Taro Amagata,* Keiko Takigawa, Katsuhiko Minoura, and Atsushi Numata*

*Department of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Ave., San Francisco, CA 94132, U.S.A.

Abstract

The Halichondria sponge-derived fungus, Gymnascella dankaliensis, was cultured in a malt extract medium containing the bromine source. Three new metabolites, gymnastatins I (5)–K (7), have been isolated from the mycelial MeOH extract. The spectroscopic analyses using 1D and 2D NMR techniques have established the stereostructures of 57 in which chlorine atoms in gymnastatins A (1)–C (3) are respectively replaced by bromine atoms. All of the isolated metabolites (57) exhibited growth inhibition against the P388 cancer cell line. Furthermore, gymnastatins I (5) and J (6) showed appreciable growth inhibition against the human cancer cell lines.