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Paper | Regular issue | Vol 81, No. 4, 2010, pp.867-882
Published online, 9th February, 2010
DOI: 10.3987/COM-09-11877
Synthesis of Bis-Aryl Phosphates Based on Triazine Scaffold

Caroline Courme, Nohad Gresh, Christine Lenoir, Michel Vidal, Christiane Garbay, Jean-Claude Florent, and Emmanuel Bertounesque*

*Medicinal Chemistry, C.N.R.S. UMR 176, 26 rue d’Ulm, Paris 75005, France

Abstract

In view of targeting the Grb2-SH2 signaling protein, the synthesis of potential ligands based on the 1,3,5-triazine scaffold bearing two phenylphosphate groups is described. The triazine functionality was introduced using an orthogonal strategy via the sulfone chemistry.