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Note | Regular issue | Vol 81, No. 1, 2010, pp.171-174
Published online, 2nd November, 2009
DOI: 10.3987/COM-09-11848
A Non-Catalyst Method for the Synthesis of Bis-4-aryl-3,4-dihydropyrimidones (thiones) under Solvent-Free Conditions

Chhanda Mukhopadhyay* and Arup Datta

*Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata-700009, India


Three component coupling of an aromatic dialdehyde, a β-keto ester or β-diketone and urea or thiourea (1:2.2:2.5 mol ratios) in one–pot under solvent-free conditions without any catalyst produced the bis-dihydropyrimidones (thiones) in a microwave oven. This is therefore a “green” synthesis of the title compounds under the said conditions.