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Review | Regular issue | Vol 81, No. 1, 2010, pp.57-66
Published online, 17th November, 2009
DOI: 10.3987/REV-09-660
Artificial Macrosphelides as a Novel Apoptosis-Inducing Compound

Yuji Matsuya* and Hideo Nemoto

*Faculty of Pharmaceutical Sciences, Toyama University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.