Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 78, No. 12, 2009, pp.2943-2949
Published online, 2nd October, 2009
DOI: 10.3987/COM-09-11820
Regioselective Ester Hydrolysis of Sialic Acid Derivatives Catalyzed by Molecularly Imprinted Polymers

Kiyoshi Ikeda,* Takashi Katsumata, Yuji Sugiyama, Keisuke Miyamoto, Kiyoshi Tanaka, and Masayuki Sato

*Department of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima, 737-0112, Japan

Abstract

Regioselective ester hydrolysis of sialic acid derivatives catalyzed by molecularly imprinted polymers was studied. A sialic acid derivative having 8-O-methylphosphonate was used as the template for molecular imprinting polymer (MIP). By mimicking the tetrahedral intermediate for ester hydrolysis, this MIP catalyzed the regioselective hydrolysis of the 8-O-acetyl group of per-O-acetylated sialic acid derivative at an increased rate.