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Note | Regular issue | Vol 81, No. 1, 2010, pp.145-148
Published online, 9th November, 2009
DOI: 10.3987/COM-09-11804
Synthesis of Arnoamine B

Shinsuke Nakahara,* Toshiyuki Sadachi, and Akinori Kubo

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


The synthesis of arnoamine B (2), which inhibits the catalytic activity of topoisomerase II and exhibits selective cytotoxicity against human tumor cell lines, was achieved in six steps from 5-methoxy-6-nitroindole (3) in 33 % overall yield.