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Note | Regular issue | Vol 78, No. 9, 2009, pp.2369-2376
Published online, 21st May, 2009
DOI: 10.3987/COM-09-11741
A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata

Hidefumi Makabe,* Asuka Kuwabara, Yasunao Hattori, and Hiroyuki Konno

*Shinshu University, 8304 Minamiminowa-mura, Kamiina-gun, Nagano 399-4598, Japan


A concise total synthesis of solamin (1) and cis-solamin (2) was performed using an epoxy alcohol (11) as a versatile chiral building block for synthesizing the stereoisomers of the mono-THF annonaceous acetogenins.