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Note | Regular issue | Vol 78, No. 8, 2009, pp.2107-2113
Published online, 21st April, 2009
DOI: 10.3987/COM-09-11704
First Synthesis of Racemic Concentricolide, an Anti-HIV-1 Agent Isolated from the Fungus Daldinia concentrica

Li-Zhen Fang and Ji-Kai Liu*

*State Key Laboratory of Phytochemistry and
Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, Yunnan, China

Abstract

Concentricolide, a novel compound with anti-HIV-1 activity and isolated from ascomycete Daldinia concentrica, has been synthesised for the first time as a racemate from furan-3-carbaldehyde and dihydrofuran-2(3H)-one via a Diels-Alder reaction. The identity of the synthetic sample was verified by comparison of its spectral data with those of an authentic sample.