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Communication | Special issue | Vol 80, No. 2, 2010, pp.847-854
Published online, 11th September, 2009
DOI: 10.3987/COM-09-S(S)103
Diversity-Oriented Approach to 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives Using Diethyl Acetamidomalonate as a Glycine Equivalent: Further Expansion by Suzuki–Miyaura Cross-Coupling Reaction

Sambasivarao Kotha,* Shilpi Misra, Nimita Gopal Krishna, Nagaraju Devunuri, Henning Hopf, and Abhilash Keecherikunnel

*Department of Chemistry, Indian Institute of Technology, Powai, Mumbai 400 076, India

Abstract

Synthesis of diverse 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and its higher analogues are reported using diethyl acetamidomalonate as a glycine equivalent. In addition, various substituted Tic derivatives are assembled by application of SuzukiMiyaura cross-coupling reaction as a key step.