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Communication | Special issue | Vol 80, No. 2, 2010, pp.903-907
Published online, 9th November, 2009
DOI: 10.3987/COM-09-S(S)121
Synthetic Studies toward Antitumor Sesquiterpenoid Quadrone

Akihiro Ishihata, Megumi Saeki, Masaru Watanabe, Masataka Ihara, and Masahiro Toyota*

*Department of Chemistry, Graduate School of Science, University of Osaka Prefecture, Sakai, Osaka 593-8531, Japan


A palladium-catalyzed cycloalkenylation and an acid-promoted intramolecular Michael reaction were utilized as the key steps in a synthetic approach to sesquiterpene quadrone 1. This route capitalizes upon the ability of the above reactions to stereoselectively assemble tricyclic core 15 of quadrone 1.