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Communication | Special issue | Vol 80, No. 2, 2010, pp.825-830
Published online, 3rd September, 2009
DOI: 10.3987/COM-09-S(S)93
Synthesis of the ABC Ring Fragment of Brevisin, a New Dinoflagellate Polycyclic Ether

Naohito Ohtani, Ryosuke Tsutsumi, Takefumi Kuranaga, Tomohiro Shirai, Jeffrey L. C. Wright, Daniel G. Baden, Masayuki Satake,* and Kazuo Tachibana*

*Department of Chemistry, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan


A polycyclic ether, brevisin was isolated from the red-tide dinoflagellate Karenia brevis. Its unique skeletal structure consists of two separate tricyclic ether assemblies connected by a methylene bridge. The ABC ring fragment of brevisin was synthesized via Suzuki–Miyaura cross coupling toward a total synthesis of brevisin.