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Communication | Special issue | Vol 80, No. 2, 2010, pp.873-877
Published online, 25th September, 2009
DOI: 10.3987/COM-09-S(S)111
Synthesis of Zanthoxyline and Its Related Compounds: Revision of the Reported Structure

Hitoshi Abe,* Naoko Kobayashi, Yasuo Takeuchi, and Takashi Harayama*

*Department of Applied Chemistry, Faculty of Engineering, Toyama University, Gofuku 3190, Toyama 930-8555, Japan


Benzo[c]phenanthridine alkaloid, zanthoxyline, was synthesized through an intramolecular biaryl coupling reaction of N-naphthylbenzamide derivative using a palladium reagent. Comparison of the NMR data for the synthetic product with that reported previously revealed that the proposed structure was incorrect. Synthesis of the related compounds suggested that the correct structure of zanthoxyline is the previously known decarine.