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Note | Regular issue | Vol 78, No. 8, 2009, pp.2085-2092
Published online, 14th April, 2009
DOI: 10.3987/COM-09-11693
α’-Oxoperakensimines A - C, New Bisbenzylisoquinoline Alkaloids from Alseodaphne perakensis (Gamble) Kosterm

Mat Ropi Mukhtar, Mohd Azlan Nafiah, Khalijah Awang, Noel F. Thomas, Kazumasa Zaima, Hiroshi Morita, Marc Litaudon, and A. Hamid A. Hadi*

*Department of Chemistry, Faculty of Science, University of Malaya, Pantai Valley, 50603 Kuala Lumpur, Malaysia

Abstract

Three new bisbenzylisoquinolines, α′-oxoperakensimines A – C (13) have been isolated from the bark of Alseodaphne perakensis (Gamble) Kosterm (Lauraceae). Their structures were elucidated by two-dimensional NMR techniques. α′-Oxoperakensimines A – C (13) showed vasorelaxant activity on rat aorta.