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Note | Regular issue | Vol 78, No. 8, 2009, pp.2053-2059
Published online, 16th April, 2009
DOI: 10.3987/COM-09-11671
New Alkaloids from Conchocarpus gaudichaudianus

Lucia E. Ranieri Cortez, Diógenes A. Garcia Cortez,* João B. Fernandes, Paulo C. Vieira, Antonio G. Ferreira, and M. Fátima das G. F. da Silva

*Department of Pharmacy and Pharmacology, State University of Maringá, Av. Colombo, 5790
CEP 87020-090, Maringá, Paraná, Brazil

Abstract

The methanol extract from stems of Conchocarpus gaudichaudianus yielded four new alkaloids: 3-(2-(7,7-dimethyl-3,7-dihydropyrano[3,2-e]indol-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione (1), 3-(2-(7,7-dimethyl-3,7-dihydropyrano[3,2-e]indol-1-yl)ethyl)-1-hydroxyquinazoline-2,4(1H,3H)-dione (2), 3-(2-(7,7-dimethyl-3,7-dihydropyrano[3,2-e]indol-1-yl)ethyl-1-methylquinazoline-2,4(1H,3H)-dione (3), (E)-3-(6,7-dihydroxy-3,7-dimethyloct-2-enyl)-4-methoxy-1-methylquinolin-2(1H)-one (6), in addition to the known alkaloids N-trans-coumaroyltyramine and N-trans-feruloyltyramine. The structures of these compounds were identified by IR, UV, 1H and 13C NMR spectroscopy, gHSQC and gHMBC spectral analysis and comparison of data from the literature.