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Note | Regular issue | Vol 78, No. 5, 2009, pp.1309-1316
Published online, 30th January, 2009
DOI: 10.3987/COM-08-11630
Chemical Constituents and Cytotoxicity from the Stem Bark of Citrus medica

Yu-Yi Chan, Tian-Shung Wu,* and Yao-Haur Kuo

*Department of Chemistry, National Cheng Kung University, 1, Ta-Shiueh Rd., Tainan 70101, Taiwan, R.O.C.

Abstract

A new biscoumarin, namely citrumedin-A [6,6',7,7'-tetramethoxy- 3,3'-biscoumarin] (1), together with twenty two known compounds were isolated from the stem bark of Citrus medica L. var. sarcodactylis Swingle. The structure of this new compound was completely elucidated using a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-EI-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literatures. The isolates were also screened their cytotoxicity against Daoy, Hep2, MCF-7 and Hela cell lines. Lonchocarpol A (12) showed marginally cytotoxic activity against those four cancer cell lines.