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Paper | Regular issue | Vol 78, No. 5, 2009, pp.1253-1263
Published online, 20th January, 2009
DOI: 10.3987/COM-08-11625
Eremophilane Derivatives from Pittocaulon praecox

Amira Arciniegas,* Ana-L. Pérez-Castorena, Erick Gastélum, José Luis Villaseñor, and Alfonso Romo de Vivar

*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., Mexico


Five new compounds; two eremophilane glucosides (1, 2) and three eremophilanolides (3, 11, 12), together with several known compounds were isolated from Pittocaulon praecox. Their structures were elucidated by spectroscopic methods. The anti-inflammatory activity of extracts and main isolated metabolites was evaluated on 2-O-tetradecanoylphorbol-13-acetate (TPA) induced model of acute inflammation.