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Note | Regular issue | Vol 78, No. 5, 2009, pp.1271-1279
Published online, 29th January, 2009
DOI: 10.3987/COM-08-11614
■ Synthesis of Quinolizino[3,2-a]quinolizine Derivatives and Their Fluorescence

Kenichirou Yokota, Masayori Hagimori, Yasuhiro Shigemitsu, Naoko Mizuyama, Bo-Cheng Wang, and Yoshinori Tominaga*

*School of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

Polycyclic quinolizine derivatives, quinolizino[3,2-a]quinolizines (4a–c), were synthesized in moderate yields by a one-pot method using ketene dithioacetal, methyl bis(methylsulfanyl)methylene-cyanoacetate (2), alkyl 2-pyridylacetates (1a, b), and 2-pyridylacetonitrile (1c). Compounds 4a, b exhibited red fluorescence (Em max: 576 nm) in solid state.