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Note | Regular issue | Vol 78, No. 4, 2009, pp.1031-1039
Published online, 9th December, 2008
DOI: 10.3987/COM-08-11586
A Convenient One-Pot Synthesis of Arene-Centered Tris(thiazoline) Compounds

Xuhong Lu, Qingqing Qi, Yumei Xiao, Nan Li, and Bin Fu*

*Department of Applied Chemistry, College of Science, China Agriculural University, Beijing, 100094, China

Abstract

A simple and practical one-pot synthesis of novel enantiopure tris(thiazoline) compounds was documented. The desired products were obtained in moderate to good yields through three steps from commercially available 1, 3, 5-benzenetricarboxylic acid or 2, 4, 6-pyridinetricarboxylic acid, and chiral amino alcohols. Only one column chromatographic purification was needed for the three steps.