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Communication | Special issue | Vol 77, No. 1, 2009, pp.151-155
Published online, 11th April, 2008
DOI: 10.3987/COM-08-S(F)5
Use of NaOH as a New Activator for the Palladium-Catalyzed Direct CH Arylation of Thiazole Derivatives

Takayuki Miyaoku and Atsunori Mori*

*Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan


Sodium hydroxide is found to serve as a new activator for the palladium-catalyzed C-H arylation of thiazole derivatives with aryl bromides and aryl iodides. The reaction of benzothiazole proceeds smoothly with 4-bromoanisole to afford the corresponding coupling product in an excellent yield.