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Paper | Regular issue | Vol 78, No. 2, 2009, pp.415-423
Published online, 9th October, 2008
DOI: 10.3987/COM-08-11522
One-Pot Three Component Reaction for the Synthesis of 2-Alkylthio-3-aroylimidazo[2,1-a]isoquinoline in Aqueous Media

Ebrahim Kianmehr,* Reza Faramarzi, and Hamid Estiri

*School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455 Tehran, Iran


A one-pot, three component reaction between isoquinoline, phenacyl bromide derivatives and thiocyanates leading to imidazo[2,1-a]isoquinoline derivatives in good yields is reported. Reactions are carried out in water or DMF as the solvent at reflux.