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Paper | Regular issue | Vol 78, No. 1, 2009, pp.151-159
Published online, 16th September, 2008
DOI: 10.3987/COM-08-11512
Synthesis and Antimicrobial Evaluation of New Thiophene and 1,3,4-Thiadiazole Derivatives

Mohamed R. Shaaban, Tamer S. Saleh, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt


A Facile route to some new thiophene derivatives via the reaction of 3-mercapto-2-(1-methylbenzimidazole-2-carbonyl)-3-phenylaminopropenal (3) with 1-aryl-2-bromoethanones, chloroacetonitrile and ethyl bromoacetate is reported. Reaction of 3 with hydrazonoyl halides afforded 1,3,4-thiadiazole derivatives incorporating a benzimidazole moiety. Antimicrobial and antifungal activities of selected examples of the new products were evaluated.