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Communication | Special issue | Vol 77, No. 1, 2009, pp.207-210
Published online, 31st July, 2008
DOI: 10.3987/COM-08-S(F)35
Synthesis and Biological Properties of a Rhodacyanine Derivative, SSJ-127, having High Efficacy against Malaria Protozoa

Khanitha Pudhom, Jian-Feng Ge, Chika Arai, Mei Yang, Mercel Kaiser, Sergio Wittlin, Reto Brun, Isamu Itoh, and Masataka Ihara*

*Research Centre of Medicinal Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


One of rhodacyanine derivatives, SSJ-127 (1), showed a complete cure of a mouse model infected with Plasmodium berghei by subcutaneous administration. The synthesis, in vitro activities against several protozoa and in vivo antimalarial test and PK study of SSJ-127 (1) are reported.