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Note | Regular issue | Vol 75, No. 12, 2008, pp.3057-3064
Published online, 4th August, 2008
DOI: 10.3987/COM-08-11440
Coumarins and Flavones from Casimiroa pringlei

Emma Maldonado, Imelda Márquez, Fernando Chiang, and Alfredo Ortega*

*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., México


A chemical study of the leaves of Casimiroa pringlei led to the isolation of six coumarins, six flavones and the sesquiterpene, cryptomeridiol. Four of these compounds are new natural products which, on the basis of spectroscopic analyses, were characterized as (Z)-trichoclin acetate, 5,3’,5’-trimethoxyflavone, 5,2’,3’,4’-tetramethoxyflavone, and 5,2’,3’,4’,5’,6’-hexamethoxyflavone. Although 5,2’,3’,4’-tetramethoxyflavone has been obtained by synthesis, this is the first report of its isolation from a natural source.