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Note | Regular issue | Vol 75, No. 12, 2008, pp.3051-3056
Published online, 10th July, 2008
DOI: 10.3987/COM-08-11438
Singaporentine A: A New Indole Alkaloid from Kopsia singapurensis Ridl.

Khalijah Awang,* Kartini Ahmad, Noel F. Thomas, Yusuke Hirasawa, Koichi Takeya, Mat Ropi Mukhtar, Khalit Mohamad, and Hiroshi Morita

*Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

Study on chemical constituents from the leaves of Kopsia singapurensis (Apocynaceae) yielded a new indole alkaloid, singaporentine A (1) together with two known alkaloids, kopsifoline A (2) and kopsininic acid (3). The structure of 1 was elucidated by combination of various spectroscopic methods such as MS, UV, IR, 1D and 2D NMR. Singaporentine A exhibited cytotoxic activity against P388 murine leukemia cells.