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Review | Regular issue | Vol 75, No. 12, 2008, pp.2893-2929
Published online, 24th July, 2008
DOI: 10.3987/REV-08-634
Reaction of Hydrazines and Hydroxylamine with Trifluoromethyl-β-diketones: Synthesis of Trifluoromethylpyrazole and Isoxazole Derivatives

Vinod Kumar, Ranjana Aggarwal, and Shiv P. Singh*

*Department of Chemistry, Kurukshetra University, Kurukshetra -136 119, India

Abstract

The reaction of trifluoromethyl-β-diketones with hydrazines and hydroxylamine finds interesting application in the synthesis of trifluoromethylpyrazole and isoxazole derivatives. The review covers the literature of the reactions mentioned up to 2007. Mechanistic aspects leading to the formation of these heterocycles and their NMR spectral characteristics are also described.