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Communication | Special issue | Vol 25, No. 1, 1987, pp.151-153
Published online, 1st January, 1970
DOI: 10.3987/S-1987-01-0151
A Novel synthesis of (±)-Noraporphine Alkaloids, (±)-Wilsonirine and (±)-Nordomesticine

Osamu Hoshino, Hiromichi Ogasawara, Masaji Suzuki, and Bunsuke Umezawa

*Faculty of Pharmaceutical Sciences,. Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Abstract

(±)-Wilsonirine (1a) and (±)-nordomesticine (1b) were synthesized in moderate yields on acid treatment, followed by alkaline hydrolysis of o-quinol acetates (o-QAs) (3) readily obtained by lead tetraacetate oxidation of (±)-N-trifluoroacetyltetrahydroisoquinolin-7-ols (2).