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Communication | Special issue | Vol 25, No. 1, 1987, pp.113-116
Published online, 1st January, 1970
DOI: 10.3987/S-1987-01-0113
An Asymmetric Total Synthesis of Unnatural (+)-Anisomycin

A. I. Meyers and Brian Dupre

*Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, U.S.A.

Abstract

Utilizing the valine-based chiral formamidine of 2,5-dihydropyrrole, enantioselective alkylation with p-methoxybenzyl chloride gave, after several subsequent synthetic manipulations, the unnatural enantiomer, (±)-anisomycin, in 22% overall yield and 88-90% ee.