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■ Microbial Transformation of 2’-Propoxy Analogs of (-)- and (+)-Dehydrogriseofulvin and (+)-2’-Demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

Yoshihiro Sato* and Taiko Oda

*Faculty of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, 1-5-30, Shiba-koen, Minato-ku, Tokyo 105-8512, Japan

Abstract

By the fermentation of Streptomyces cinereocrocatus, 2’-propoxy analogs of (-)- and (+)-dehydrogriseofulvin were both converted into the corresponding analog of (+)-griseofulvin and the same treatment of (+)-2’-demethoxydehydrogriseofulvin afforded (+)-2’-demethoxygriseofulvin and (+)- and (-)-2’-demethoxy-2’,3’-dihydrodehydrogriseofulvin, indicating that the (+)-substrates were isomerized into the corresponding (-)-enantiomers and subsequently transformed to the reduction products.