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Communication | Special issue | Vol 17, No. 1, 1982, pp.151-154
Published online, 1st January, 1970
DOI: 10.3987/S-1982-01-0151
Hydroxylation of Alkyl Groups on the Pyrazine Ring

Akihiro Ohta* and Minoru Ohta

*Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Treatment of THF solutions of 2,5-dialkylpyrazine 1-oxides with oxygen in the presence of bases gave the corresponding 2-hydroxypyrazine 1-oxides and dimers. On the other hand, when 2-chloro-3,6-dialkylpyrazine 1-oxides and 3,6-dialkyl-2-hydroxypyrazine 1-oxides were treated under the same conditions, hydroxylation occurred successfully at the α-position of the side chain.