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Communication | Special issue | Vol 17, No. 1, 1982, pp.49-52
Published online, 1st January, 1970
DOI: 10.3987/S-1982-01-0049
A New Efficient Coupling Reagent for Cyclic N -Methylanilide Formation

Masayuki Shimagaki, Hiroko Koshiji, and Takeshi Oishi*

*The Institute of Physical and Chemical Research, Wako-shi, Saitama 351-0198, Japan

Abstract

Treatment of the reagent (5) with the amino acid (11) in DMF afforded the active ester (12), which was added slowly to toluene at 95-100°C to produce the 15-membered cyclic N-methylanilide (13). The reaction proceeds under essentially neutral conditions.