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Communication | Special issue | Vol 15, No. 2, 1981, pp.819-822
Published online, 1st January, 1970
DOI: 10.3987/S-1981-02-0819
Synthesis of Nicotianamine and a Related Compound,Derivatives of Azetidine-2-carboxylic Acid

Shinji Fushiya, Shuichi Nakatsuyama, Yoshikazu Sato, and Shigeo Nozoe*

*Pharmaceutical Institute, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan


The synthesis of nicotianamine (1) and a related compound (2) — amino acid derivatives having the azetidine ring — was achieved by reductive coupling of L-aspartic-β-semialdehyde derivatives with L-azetidine-2-carboxylic acid methyl ester.