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Communication | Special issue | Vol 15, No. 2, 1981, pp.735-738
Published online, 1st January, 1970
DOI: 10.3987/S-1981-02-0735
■ Acylation of Acyclic Enamines with an Excessive Amount of Pyridinecarbonyl Chlorides

Takeaki Naito and Ichiya Ninomiya*

*Kobe Women’s College of Pharmacy, Motoyamakita, Higashinad, Kobe, Hyogo 658, Japan

Abstract

Acylation of the acyclic enamines (1a and d) and (6a) with an excessive amount of isonicotinoyl or nicotinoyl chloride provided a simple preparation of the spiranes (2, 3, and 7) or the 1,6-naphthyridines (4 and 5) respectively, of which the latter has an analogous structure of nalidixic acid, a powerful antibacterial agent.