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Communication | Special issue | Vol 15, No. 1, 1981, pp.237-240
Published online, 1st January, 1970
DOI: 10.3987/S-1981-01-0237
A Facile Synthesis of a Nuphar Alkaloid, Nupharolutine

Mitsutaka Natsume* and Masashi Ogawa

*Research Foundation Itsuu Laboratory, 2-28-10 Tamagawa, Setagaya-ku, Tokyo 158, Japan

Abstract

A regio- and stereoselective synthesis of (±)-nupharolutine (2) was achieved starting from 3-methylpyridine by utilizing the SnCl2-effected reaction of endoperoxide of a 1,2-dihydropyridine derivative 5.