Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 13, No. 1, 1979, pp.477-495
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0477
Structures of Bu-2313 A and B, New Anti-anaerobic Antibiotics and Syntheses of Their Analogs

Susumu Nakagawa,* Takayuki Naito, and Hiroshi Kawaguchi

*Bristol-Banyu Research Institute, Ltd., 2-9-3, Shimomeguro, Meguro, Tokyo 153, Japan

Abstract

An oligosporic actinomycete strain, No. E864-861, produced two new antibiotics, Bu-2313 A (C27H35NO9) and Bu-2313 B (C26H33NO9). Both Bu-2313 A and B exhibited a broad antimicrobial spectrum against gram-positive and gram-negative anaerobic bacteria, and also inhibited the growth of some aerobic bacteria such as streptococci. The structures of Bu-2313 A and B have been elucidated. They belong to the family of antibiotics classified as dienoyltetramic acids. Semi-synthesis of Bu-2313 A and B was performed by C-acylation of tetramic acids with the dienoic moiety obtained by periodate oxidation of Bu-2313. In a similar manner Bu-2313 analogs were prepared by using a variety of tetramic acids and cyclic 1,3-diketones.