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Communication | Special issue | Vol 13, No. 1, 1979, pp.411-467
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0411
Synthetic Studies on Mitomycins and Related Compounds

Kimio Takahashi and Tetsuji Kametani*

*Pharmaceutical Institute, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan


Synthetic approaches towards mitomycins and their analogs are described. The strategy of this study includes a simple synthesis of mitosene derivatives and their transformation to seco-mitosane type compounds which have been shown to be key intermediates in the total synthesis of the mitomycins. Synthetic studies on mitomycins appearing in the literature are also reviewed.