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Communication | Special issue | Vol 13, No. 1, 1979, pp.239-246
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0239
A Convenient Synthesis of 1,4-Dihydro-4-oxonicotinic Acid Derivatives

Osamu Makabe,* Yasushi Murai, and Shunzo Fukatsu

*Library, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Abstract

The cyclization of β-ketoesters with β-aminocrotonates in the presence of molecular sieves gave 6-substituted or 5,6-disubstituted-1,4-dihydro-4-oxonicotinic acid esters by one step reaction.