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Communication | Special issue | Vol 13, No. 1, 1979, pp.235-238
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0235
Studies on Pyrimidine Derivatives. XVII. Synthesis of Pyrimidine-4-carboxylic Esters

Takeji Sakasai, Takao Sakamoto, and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

During the controlled oxidation of polymethylpyrimidines with selenium dioxide in pyridine, it was observed that the 4-methyl group on the pyrimidine ring was selectively oxidized to give pyrimidine-4-carboxylic acids. In addition to this investigation, the transformation of pyrimidinecarboxamides into methyl pyrimidinecarboxylates was successfully achieved in methanol in the presence of boron trifluoride etherate.